It is a well known fact that the easiest way to acquire that thick, juicy, sought after sound of graet Stevie Ray Vaughan (besides heavy fingerwork and a strong right hand technique) is by using an old Fender Stratocaster (1959 preferably) with vintage type pickups ( Fender Fat 50s or Tex Mex), Fender Vibroverb amp and a Tubescreamer pedal. However there are other ways of using your guitar sound effects and your gear to get similar sound.
One way I came across was with my Fox Stratocaster, Mesa/Boogie Stiletto Deuce Amp and a Boss SD1 Overdrive.
On my guitar I used the neck pickup.
The settings on the Boss SD1 are: Level – 11 o clock, Tone – 11 o clock, Drive – 9 to 11 o clock. The pedal is used more like a booster and not a real overdrive. It doesnt even have much drive. It is subtile, smooth, very transparent and responsive to your picking technique. In this context I use it just to shape my tone a little and it makes it possible to achieve that tube sound that is on the verge of breakup even on bedroom levels.
Keep in mind:
1. My Stratocaster body is made of one piece mahagony, therefore it has much tighter bass and midrange than an usual Strat so you might want to try different settings on the amp and the pedal in order to get this sound.
2. If you know anything about Mesa/Boogie Stiletto amps then you know that it is an awesome amp with surprisingly beautiful clean and numerous possibilities, but is also sometimes hard to tame. Stiletto is not an usual Boogie. It is actually based on british amps like Marshall (it even uses EL34 power tubes found in Marshall amps) but is much more versatile and offers much more possibilities than a typical Marshall. It has a Marshall-like sound but still retains the Boogie character (especially on the channel 2 – the overdrive channel). You can shape your clean channel gain with the fat/tite/crunch switch (fat being for sweeter vintage bluesier sound reminiscent of SRV, tite for more focused tighter british clean sound and crunch that roams from brit blues to UK hard rock). Channel 2 offers a clone of channel 1 crunch mode and delivers two different Hi Gain modes (Tite gain for a hard rock mid attack and sustain, and Fluid Drive for harmonically ritch solos).
The bottom line is: this amp and this pedal can take you right to the Texas Flood teritory if you spend some time on the settings. Yes, it is possible to get it with the gear other than a Tubescreamer plugged into a Fender amp. Tubescreamer did not make Stevie famous, its the other way around.